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1UHO  Download PDB file  Display PDB file
DOI 10.2210/pdb1uho/pdb
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Red - Derived Information
Title Crystal structure of Human Phosphodiesterase 5 complexed with Vardenafil(Levitra)
Authors Sung, B.-J.,  Lee, J.I.,  Heo, Y.-S.,  Kim, J.H.,  Moon, J.,  Yoon, J.M.,  Hyun, Y.-L.,  Kim, E.,  Eum, S.J.,  Lee, T.G.,  Cho, J.M.,  Park, S.-Y.,  Lee, J.-O.,  Jeon, Y.H.,  Hwang, K.Y.,  Ro, S.
Primary Citation 		Sung, B.-J.,  Hwang, K.Y.,  Jeon, Y.H.,  Lee, J.I.,  Heo, Y.-S.,  Kim, J.H.,  Moon, J.,  Yoon, J.M.,  Hyun, Y.-L.,  Kim, E.,  Eum, S.J.,  Park, S.-Y.,  Lee, J.-O.,  Lee, T.G.,  Ro, S.,  Cho, J.M. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature v425 pp. 98-102, 2003
[ Abstract ]    View PubMed Abstract at NCBI
History Deposition   2003-07-09  Release  2004-07-09
Experimental Method Type   X-RAY DIFFRACTION Data Download Structure Factors  [ EDS ]
Parameters
Resolution[Å] View a histogram of Resolution R-Value R-Free Space Group
2.50 0.197 (obs.) 0.210 C 2 2 21
Unit Cell
Length [Å] a 60.52 b 156.72 c 89.98
Angles [°] alpha 90.00  beta 90.00  gamma 90.00 
Molecular Description Asymmetric Unit

Polymer: 1   Molecule: cGMP-specific 3',5'-cyclic phosphodiesterase   Fragment: catalytic domain   Chains: A   EC no.: 3.1.4.17 Go to IUBMB EC entry   
Classification Hydrolase      
Source
Polymer:  1    Scientific Name:  Homo sapiens   Go to NCBI Taxonomy entry Common Name:  Human   Expression system:  Escherichia coli  
Link out to BindingDB:1UHO Ligand Chemical Component
Identifier Name Formula Drug Similarity Hapten Similarity Ligand Structure Ligand Interaction  
MG   MAGNESIUM ION  Mg   Link out to SuperLigands:MG Link out to SuperHapten:MG [ View ] [ View ]
VDN   2-{2-ETHOXY-5-[(4-ETHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}- 5-METHYL-7-PROPYLIMIDAZO[5,1-F][1,2,4]TRIAZIN- 4(1H)-ONE  C23 H32 N6 O4 S   Link out to SuperLigands:VDN Link out to SuperHapten:VDN [ View ] [ View ]
ZN   ZINC ION  Zn   Link out to SuperLigands:ZN Link out to SuperHapten:ZN [ View ] [ View ]
SCOP Classification (version 1.71)
Domain Info Class Fold Superfamily Family Domain Species
d1uhoa_ All alpha proteins HD-domain/PDEase-like HD-domain/PDEase-like PDEase cGMP-specific 3',5'-cyclic phosphodiesterase pde5a1- Ibmx Human (Homo sapiens)
CATH Classification (version v3.1.0)
Domain Class Architecture Topology Homology
1uhoA00 Mainly Alpha Orthogonal Bundle Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
GO Terms
Polymer Molecular Function Biological Process Cellular Component
cGMP-specific 3',5'-cyclic phosphodiesterase (1UHO:A)
  • none
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